ChemicalBook > CAS DataBase List > CH5138303
CH5138303
- Product Name
- CH5138303
- CAS No.
- 959763-06-5
- Chemical Name
- CH5138303
- Synonyms
- CH5138303;CH5138303cas;CH5138303_Hsp90;CH5138303 USP/EP/BP;4-[[4-Amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]butanamide;4-[4-amino-6-(5-chloro-1H,3H-benzo[de]isochromen-6-yl)-1,3,5-triazin-2-ylsulfanyl]butanamide;4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[de]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamid;Butanamide, 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-;4-[(4-Amino-6-[7-chloro-3-oxatricyclo[7.3.1.0(5,13)] trideca-1(13),5,7,9,11-pentaen-8-yl]-1,3,5-triazin-2-yl)sulfanyl]butanamide
- CBNumber
- CB72706190
- Molecular Formula
- C19H18ClN5O2S
- Formula Weight
- 415.9
- MOL File
- 959763-06-5.mol
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CH5138303 Property
- Boiling point:
- 813.1±75.0 °C(Predicted)
- Density
- 1.51±0.1 g/cm3(Predicted)
- storage temp.
- Desiccate at -20°C
- solubility
- insoluble in H2O; insoluble in EtOH; ≥19.95 mg/mL in DMSO
- form
- solid
- pka
- 16.39±0.40(Predicted)
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 22417
- Product name
- CH5138303
- Purity
- ≥99%
- Packaging
- 1mg
- Price
- $117
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 22417
- Product name
- CH5138303
- Purity
- ≥99%
- Packaging
- 5mg
- Price
- $404
- Updated
- 2024/03/01
ApexBio Technology
- Product number
- B4571
- Product name
- CH5138303
- Packaging
- 1mg
- Price
- $67
- Updated
- 2021/12/16
AK Scientific
- Product number
- 2164AH
- Product name
- 4-((4-Amino-6-(5-chloro-1,3-dihydrobenzo[DE]isochromen-6-yl)-1,3,5-triazin-2-yl)thio)butanamide
- Packaging
- 1mg
- Price
- $228
- Updated
- 2021/12/16
ApexBio Technology
- Product number
- B4571
- Product name
- CH5138303
- Packaging
- 5mg
- Price
- $237
- Updated
- 2021/12/16
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CH5138303 Chemical Properties,Usage,Production
Description
CH5138303 is a triazine Hsp90 inhibitor. CH5138303 binds to the N-terminus of Hsp90α (Kd = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED50 = 3.9 mg/kg) and displays high oral bioavailability in mice.
target
Hsp90
References
[1]. suda a, kawasaki k, komiyama s, et al. design and synthesis of 2-amino-6-(1h,3h-benzo[de]isochromen-6-yl)-1,3,5-triazines as novel hsp90 inhibitors. bioorg med chem, 2014, 22(2): 892-905.
CH5138303 Preparation Products And Raw materials
Raw materials
Preparation Products
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CH5138303 Suppliers
- Tel
- +1 (866) 930-6790
- Fax
- +1 (866) 333-9607
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- Country
- United States
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- United States
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- +1-708-310-1919 +1-13798911105
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- United States
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- Tel
- +1-833-552-7181
- sales@aladdinsci.com
- Country
- United States
- ProdList
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- Advantage
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- Tel
- +1-781-999-5354
- support@targetmol.com
- Country
- United States
- ProdList
- 19973
- Advantage
- 58
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